I want to go Bittrex or Poloniex with my Nubits.
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Bittrex has a higher fee
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Poloniex has higher daily volume exchange-wide. Whether this means a greater or a smaller chance of exchange default is your own guess.
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Polo has higher daily nbt volume. This can mean profits for the provider because of the spread, however it usually means a loss because people may trade well when shorting you.
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The pools may fill up. Polo has a 20k cap and bittrex has a 5k cap (per side). If the pool is full you’re better off going to the other pool instead. A full pool greatly reduces reward.