It depends on the duration of multi-sig holding, the longer, the less money I can trust.
For B&C exchange, I don’t mind reputed signers holding my $50,000 value BTC temporarily, because I’ll retrive my money within several minutes after order completed.
For one year multi-sig holding by top 12 reputed signers, I can put $10,000 into it.
For one year multi-sig holding by random 12 signers among 1000 signers, I choose only $500, because I can still fall asleep if I lose that money. And I belive $500 deposite B&C account is enough for my daily life, when money used up, just requires me to deposite more from my wallet monthly. So B&C escrow/multi-sig acount could become another Paypal.
Since our signers pool can be as big as 10,000 signers, this system can handle a mount of transaction as long as each signer is required to park some BKS in blockchain to avoid bad things. For example, one man pretents to be hundreds of signers, attackers counterfeit lots of signers.